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Nanocomposite biomaterials based on hydroxyapatite xerogel

  • Proceedings of the First All-Russian Conference “Sol-Gel Synthesis and Study of Inorganic Compounds, Hybrid Functional Materials, and Disperse Systems” (St. Petersburg, Russia, November 22–24, 2010)
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Abstract

A hydroxyapatite xerogel with high adsorption-structural characteristics and nanometer-sized crystals has been synthesized using dehydration of a hydroxyapatite gel in air at temperatures of 20–40°C with dehydrating agents, cryogenic treatment (−18 and −196°C), lyophilic drying, and vacuum conductive-sorption drying. The following nanocomposite biomaterials based on the hydroxyapatite xerogel have been prepared and investigated: hardening hydroxyapatite cements, elastic “hydroxyapatite-fiber carrier (cellulose, carbon)” composites, and hydroxyapatite coatings on titanium substrates. It has been established that the hardening calcium phosphate cements based on a 4- to 17-wt % hydroxyapatite gel and a hydroxyapatite powder are characterized by a hardening time in the interval from 1 min to 1 h and by a static strength up to 2.7 MPa. The hydroxyapatite content in the elastic composites varies from 4 to 540 mg/g depending on the type of fiber carriers and on the preparation conditions. In vitro and in vivo preclinical tests performed on rats have demonstrated that titanium implants with a biocoating based on the hydroxyapatite cement possess a high biocompatibility and a toxicological safety.

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Authors and Affiliations

  1. Institute of General and Inorganic Chemistry, National Academy of Sciences of Belarus, ul. Surganova 9/1, Minsk, 220072, Belarus

    O. N. Musskaya, A. I. Kulak, V. K. Krut’ko, L. A. Lesnikovich & S. A. Ulasevich

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  1. O. N. Musskaya
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  2. A. I. Kulak
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  3. V. K. Krut’ko
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  4. L. A. Lesnikovich
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  5. S. A. Ulasevich
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Correspondence to O. N. Musskaya.

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Original Russian Text © O.N. Musskaya, A.I. Kulak, V.K. Krut’ko, L.A. Lesnikovich, S.A. Ulasevich, 2011, published in Fizika i Khimiya Stekla.

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Musskaya, O.N., Kulak, A.I., Krut’ko, V.K. et al. Nanocomposite biomaterials based on hydroxyapatite xerogel. Glass Phys Chem 37, 525–532 (2011). https://doi.org/10.1134/S1087659611050075

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  • DOI: https://doi.org/10.1134/S1087659611050075

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