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  • Proceedings of the Topical Meeting of the European Ceramic Society “Structural Chemistry of Partially Ordered Systems, Nanoparticles, and Nanocomposites” (St. Petersburg, Russia, June 27–29, 2006)
  • Published:

Nanostructure ordering of proteoglycans of some biological objects


This paper reports on the results of systematic X-ray diffraction investigations into the structure of proteoglycans of the mucus and the extracellular matrix of biological tissues. The small-angle X-ray diffraction patterns of different native and modified tissues of man and animals are measured using synchrotron radiation. A comparative study of the structure of mucins from the mammal and invertebrate mucus is performed. It is demonstrated that the X-ray diffraction patterns of the mammal and invertebrate mucus are very similar to each other and exhibit a number of sharp diffraction rings with a spacing of 4.5 nm and its higher orders due to the highly ordered structure of giant proteoglycan molecules. It is revealed that the proteoglycan structure undergoes a transformation upon interaction with calcium cations. The type of X-ray diffraction pattern (“with a 4.5-nm ring” and “without a ring”) for intact tissues can be reversibly changed by treating the tissues in solutions of salts or chelating agents. The inference is made that the X-ray diffraction patterns of tissues can be used as markers for the structural transformation of the extracellular matrix under different exogenous actions.

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Original Russian Text © A.A. Vazina, N.F. Lanina, V.N. Korneev, A.M. Matyushin, A.V. Zabelin, O.V. Nayda, E.I. Maevsky, E.P. Polyakova, 2007, published in Fizika i Khimiya Stekla.

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Vazina, A.A., Lanina, N.F., Korneev, V.N. et al. Nanostructure ordering of proteoglycans of some biological objects. Glass Phys Chem 33, 294–301 (2007).

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  • Synchrotron Radiation
  • Hair Sample
  • Glass Physic
  • Hair Length
  • Duodenal Juice