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Green Synthesis and Biological Evaluation of Some 1,2,4-Triazol-3-ones

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Abstract

A series of 1,2,4-triazol-3-one derivatives were synthesized by using conventional heating and microwave irradiation techniques. Microwave syntheses of the target compounds were carried out by using both a domestic microwave oven and a monomode microwave reactor. The results showed that the use of microwave technique is advantageous in terms of time, low solvent loading, yield, and efficiency. The synthesized compounds were tested for their antioxidant and antiurease activities. The antioxidant activity was evaluated by using ABTS [2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt] radical scavenging and cupric ion reducing antioxidant capacity (CUPRAC) methods. Most of the compounds showed good antioxidant activity, especially compound 8d showed an SC50 value of 71.062±9.31 μM in comparison to Trolox used as standard (SC50 = 210.04±16.22 μM). According to the urease inhibitory activity results, most of the compounds showed better activity than thiourea (IC50 = 0.5027±0.0293 μM); in particular, compound 8a exhibited an IC50 value of 0.3070±0.0394 μM.

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Funding

The author thanks the Department of Scientific Research Project of Recep Tayyip Erdogan University for financial assistance (project no. FBA-2021-1276).

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  1. Department of Chemistry and Chemical Process Technology, Vocational School of Technical Sciences, Recep Tayyip Erdogan University, 53100, Rize, Turkey

    F. Yilmaz

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Yilmaz, F. Green Synthesis and Biological Evaluation of Some 1,2,4-Triazol-3-ones. Russ J Org Chem 60, 513–521 (2024). https://doi.org/10.1134/S1070428024030205

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