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New Synthesis of Some Isoxazole Derivatives and Their Antioxidant Properties

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Abstract

A series of substituted ethyl 5-phenyl-1,2-oxazole-3-carboxylates were synthesized in good to excellent yields in one step using hydroxylamine base and ethyl 2,4-dioxo-4-(4-R-phenyl)butanoates bearing both electron-donating and electron-withdrawing moieties on the benzene ring, and antioxidant properties of the products were investigated by the DPPH method. The proposed method is suitable for the large-scale production of isoxazole derivatives.

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Fig. 1.
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Funding

The study was financially supported by the Scientific and Technological Research Council of Turkey (TUBITAK project no. 112T503).

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  1. University of Namık Kemal, Faculty of Art and Sciences, Department of Chemistry, 59030, Tekirdag, Turkey

    N. Uludag

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  1. N. Uludag
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Uludag, N. New Synthesis of Some Isoxazole Derivatives and Their Antioxidant Properties. Russ J Org Chem 60, 490–494 (2024). https://doi.org/10.1134/S1070428024030175

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