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5-Arylpyrrolidine-2-carboxylic Acid Derivatives as Precursors in the Synthesis of Sulphonyl-substituted Pyrroles

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Abstract

cis-5-Arylpyrrolidine-2-carboxylates, obtained by 1,3-dipolar cycloaddition reactions from glycine aryl aldimines and vinyl sulfones, undergo oxidative aromatization under the action of Mn(IV) oxide to form the corresponding 5-arylpyrrole-2-carboxylates in high yields. Factors responsible for the retention of the sulfonyl substituent in the pyrrole backbone were determined.

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Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Ogarev National Research Mordovia State University, 430005, Saransk, Russia

    S. G. Kostryukov, V. A. Kalyazin, P. S. Petrov & E. V. Bezrukova

  2. Lobachevskii National Research Nizhny Novgorod State University, 603950, Nizhny Novgorod, Russia

    N. V. Somov

Authors
  1. S. G. Kostryukov
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  2. V. A. Kalyazin
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  3. P. S. Petrov
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  4. E. V. Bezrukova
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Correspondence to S. G. Kostryukov.

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Kostryukov, S.G., Kalyazin, V.A., Petrov, P.S. et al. 5-Arylpyrrolidine-2-carboxylic Acid Derivatives as Precursors in the Synthesis of Sulphonyl-substituted Pyrroles. Russ J Org Chem 60, 281–293 (2024). https://doi.org/10.1134/S1070428024020143

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