Abstract
Substituted 2,3,4,5,6,7-hexahydro-1-benzofuran-3,3-dicarbonitriles were obtained by the three-component condensation of 2-bromodimedone, aromatic aldehydes, and malononitrile.
REFERENCES
Urzúa, A., Echeverría, J., Rezende, M.C., and Wilkens, M., Molecules, 2008, vol. 13, p. 2385. https://doi.org/10.3390/molecules13102385
Witiak, D.T., Cavestri, R.C., Newman, H.A., Baldwin, J.R., Sober, C.L., and Feller, D.R., J. Med. Chem., 1978, vol. 21, p. 1198. https://doi.org/10.1021/jm00210a005
Maharvi, G.M., Ali, S., Riaz, N., Afza, N., Malik, A., Ashraf, M., Iqbal, L., and Lateef, M., J. Enzyme Inhib. Med. Chem., 2008, vol. 23, p. 62. https://doi.org/10.1080/14756360701408754
Shin, S.S., Byun, Y., Lim, K.M., Choi, J.K., Lee, K.-W., Moh, J.H., Kim, J.K., Jeong, Y.S., Kim, J.Y., Choi, Y.H., Koh, H.-J., Park, Y.-H., Oh, Y.I., Noh, M.-S., and Chung, S., J. Med. Chem., 2004, vol. 47, p. 792. https://doi.org/10.1021/jm020545z
Weidenhamer, J.D., Menelaou, M., Macias, F.A., Fischer, N.H., Richardson, D.R., and Williamson, G.B., J. Chem. Ecol., 1994, vol. 20, p. 3345. https://doi.org/10.1007/BF02033731
Wang, Q.-F., Hou, H., Hui, L., and Yan, C.-G., J. Org. Chem., 2009, vol. 74, p. 7403. https://doi.org/10.1021/jo901379h
Chuang, C.-P. and Tsai, A.-I., Synthesis, 2006, p. 675. https://doi.org/10.1055/s-2006-926300
Elinson, M.N., Vereshchagin, A.N., Stepanov, N.O., Belyakov, P.A., and Nikishin, G.I., Tetrahedron Lett., 2010, vol. 51, p. 6598. https://doi.org/10.1016/j.tetlet.2010.10.041
Elinson, M.N., Vereshchagin, A.N., Ryzhkova, Y.E., and Egorov, M.P., Mendeleev Commun., 2021, vol. 31, p.347. https://doi.org/10.1016/j.mencom.2021.04.021
Chennapuram, M., Emmadi, N.R., Bingi, C., Nanubolu, J.B., and Atmakur, K., Green Chem., 2014, vol. 16, p. 3237. https://doi.org/10.1039/c4gc00388h
Kale, A., Chennapuram, M., Bingi, C., Nanubolu, J.B., and Atmakur, K., Org. Biomol. Chem., 2015, vol. 14, p. 582. https://doi.org/10.1039/C5OB01790D
Kale, A., Medishetti, N., Nanubolu, J.B., and Atmakur, K., Synth. Commun., 2020, vol. 50, p. 3264. https://doi.org/10.1080/00397911.2020.1799013
Funding
This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors of this work declare that they have no conflicts of interest.
Additional information
Publisher’s Note. Pleiades Publishing remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Vashchenko, M.V., Andin, A.N. Three-Component Synthesis of Functionalized 2,3,4,5,6,7-Hexahydro-1-benzofuran Derivatives. Russ J Org Chem 60, 189–192 (2024). https://doi.org/10.1134/S1070428024020015
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070428024020015