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Design, Synthesis, and Antiarrhythmic Activity of New Indole-3-carboxamide Derivatives

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Abstract

The hERG potassium channel has recently received increased scientific interest due to its association with arrhythmia and sudden death from cardiovascular disease. The Kv1.5 channel, encoded by the KCNA5 gene, is a promising biotarget for the treatment of atrial fibrillation, one of the common arrhythmias. This work describes the synthesis of new amide derivatives of indole-3-carboxylic acid through its reaction with 4-[2-(diethylamino)ethoxy]aniline under the conditions of peptide synthesis in N,N-dimethylformamide. The target compounds were obtained in good yields, and their structure was studied by 1H NMR spectroscopy, mass spectrometry, and thermogravimetric analysis. The synthesized compounds were tested for antiarrhythmic activity.

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ACKNOWLEDGMENTS

The antiarrhythmic activity of the synthesized com­pounds was studied at the Chazov National Medical Research Cardiological Center, Ministry of Health of the Russian Federation.

Funding

This study was performed under financial support by the Russian Science Foundation (project no. 22-25-00258).

Author information

Authors and Affiliations

  1. Faculty of Chemistry, Moscow State University, 119991, Moscow, Russia

    Ya. B. Platonova, Z. A. Tarasov, A. N. Volov & S. V. Savilov

  2. Pirogov Russian National Research Medical University, 117997, Moscow, Russia

    N. A. Volov

  3. Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 119071, Moscow, Russia

    S. V. Savilov

Authors
  1. Ya. B. Platonova
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  2. Z. A. Tarasov
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  3. A. N. Volov
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  4. N. A. Volov
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  5. S. V. Savilov
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Corresponding author

Correspondence to Ya. B. Platonova.

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The authors declare that they have no conflicts of interest.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 12, pp. 1608–1619 https://doi.org/10.31857/S0514749223120054.

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The article is published based on the materials of the All-Russian conference with international participation “Ideas and Legacy of A.E. Favorsky in Organic Chemistry,” St. Petersburg, July 3–6, 2023. In commemoration of the 300th anniversary of St. Peters­burg State University.

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Platonova, Y.B., Tarasov, Z.A., Volov, A.N. et al. Design, Synthesis, and Antiarrhythmic Activity of New Indole-3-carboxamide Derivatives. Russ J Org Chem 59, 2092–2101 (2023). https://doi.org/10.1134/S1070428023120059

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  • DOI: https://doi.org/10.1134/S1070428023120059

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