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One-Pot Green Synthesis of 2-Amino-7,7-dimethyl-5-oxo-4-(1H-pyrazol-5-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles

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Abstract

–The one-pot three-component combinatorial synthesis of pharmaceutically active 2-amino-7,7-dimethyl-5-oxo-4-(1H-pyrazol-5-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles or -carboxylates, which involves a DBU-catalyzed reaction of 1H-pyrazole-5-carbaldehyde, 5,5-dimethylcyclohexane-1,3-dione, and malononitrile or ethyl 2-cyanoacetate at 60–65°C in ethanol for 60–90 min. The procedure offers a few advantages, including versatility, good yields, facility, and environmentally friendly conditions.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Acharya Nagarguna University, 522510, Guntur, India

    Kalyan Maram & R. Ramesh Raju

  2. Department of Chemistry, Sri Krishna Devaraya University, 515003, Anantapur, India

    K. Anitha

  3. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, 533003, Kakinada, India

    R. Sreenivasulu

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  1. Kalyan Maram
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  2. K. Anitha
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  3. R. Sreenivasulu
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  4. R. Ramesh Raju
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Maram, K., Anitha, K., Sreenivasulu, R. et al. One-Pot Green Synthesis of 2-Amino-7,7-dimethyl-5-oxo-4-(1H-pyrazol-5-yl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles. Russ J Org Chem 59, 1982–1987 (2023). https://doi.org/10.1134/S1070428023110179

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