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Synthesis of Spiro[imidazo[2,1-b]thiazole-2,3'-thiophenes] via Sulfa-Michael/Aldol Cascade Reactions

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Abstract

The sulfa-Michael/aldol cascade reaction of (Z)-2-(arylmethylene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro-2'H,3H-spiro[imidazo[2,1-b]thiazole-2,3'-thiophen]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by IR and NMR spectroscopy and HRMS, as well as XRD analysis.

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This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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  1. School of Science and Technology, Jiaozuo Teachers College, 454001, Jiaozuo, China

    Jin-Long Yan

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Yan, JL. Synthesis of Spiro[imidazo[2,1-b]thiazole-2,3'-thiophenes] via Sulfa-Michael/Aldol Cascade Reactions. Russ J Org Chem 59, 1977–1981 (2023). https://doi.org/10.1134/S1070428023110167

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