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Synthesis, Characterization and Antimicrobial Evaluation of Novel Imidazo[1,2-a]pyrazine-linked 1,2,3-Triazole Derivatives via a Click Chemistry Approach

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Abstract

This work summarizes the results of the synthesis of imidazo[1,2-a]pyrazine-linked 1,2,3-triazole derivatives and provides evidence for the importance of this motif as a lead structure for novel drug discovery. The novel synthetic approach to imidazo[1,2-a]pyrazin–1,2,3-triazole derivatives, developed in this work, is based on the click chemistry approach. Nine novel hybrid compounds were synthesized and characterized by IR and 1H and 13C NMR spectroscopy, mass spectrometry, and elemental analysis. The synthesized products were tested for antimicrobial activity against E. coli, P. aeruginosa, E. aerogenes, B. megaterium, S. aureus, and B. subtilis bacterial strains and A. niger, and A. flavus fungal strains. The antimicrobial activity was evaluated in terms of the minimum inhibitory concentration (MIC). Some of the test compounds showed a high activity antibacterial and antifungal activity.

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Fig. 1.
Scheme 1.

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ACKNOWLEDGMENTS

We would like to convey our gratitude to the Department of Chemistry, Shri M. & N. Virani Science College (Autonomous), and Rajkot, Gujarat, India for providing laboratory facilities to carry out the synthesis and antimicrobial screening of the compounds. We are also grateful to the National Facility for Drug Discovery Complex (NFDD) for instrumentation support.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Chemical Research Laboratory, Shree M. & N. Virani Science College, 360005, Rajkot, India

    R. V. Parmar & M. S. Vadodaria

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  1. R. V. Parmar
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Correspondence to R. V. Parmar.

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Parmar, R.V., Vadodaria, M.S. Synthesis, Characterization and Antimicrobial Evaluation of Novel Imidazo[1,2-a]pyrazine-linked 1,2,3-Triazole Derivatives via a Click Chemistry Approach. Russ J Org Chem 59, 1927–1939 (2023). https://doi.org/10.1134/S1070428023110118

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