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Novel Thiazole–Triazole Hybrids: Synthesis, Characterization, and Antimicrobial Evaluation

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Abstract

Previously unknown hybrid compounds comprising a thiazole and a triazole moieties were synthesized with excellent yields and characterized by IR and NMR spectroscopy, mass spectrometry, and elemental analysis. The antibacterial activity of the produced hybrid compounds was tested against bacterial (E. coli, S. aureus) and fungal (C. albicans, A. niger) strains, and the minimal inhibitory concentrations were calculated. The majority of the newly synthesized hybrids showed a moderate to an excellent antibacterial activity.

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ACKNOWLEDGMENTS

The authors are grateful to the Director of the Indian Institute of Chemical Technology, Hyderabad, Department of Chemistry of the Satavahana University, and Director of the Center for Cellular and Molecular Biology, Hyderabad, for the spectral measurements and biological activity screening.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Satavahana University, 505002, Karimnagar, India

    S. K. Manasa & M. Sarasija

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  1. S. K. Manasa
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  2. M. Sarasija
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Correspondence to M. Sarasija.

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Manasa, S.K., Sarasija, M. Novel Thiazole–Triazole Hybrids: Synthesis, Characterization, and Antimicrobial Evaluation. Russ J Org Chem 59, 1922–1926 (2023). https://doi.org/10.1134/S1070428023110106

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  • DOI: https://doi.org/10.1134/S1070428023110106

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