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Synthesis, Characterization, and Antimicrobial Evaluation of 2-Phenyl-5-{2-[3-(trifluoromethyl)phenyl]ethenyl}-1,3,4-oxadiazole Derivatives

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Abstract

A series of 2-aryl-5-{2-[3-(trifluoromethyl)phenyl]ethenyl}-1,3,4-oxadiazoles were synthesized by cyclization of 3-[3-(trifluoromethyl)phenyl]acrylic acid with substituted benzohydrazides in the presence of phosphoryl chloride. The synthesized compounds were characterized by FT-IR, 1H NMR, and mass spec­troscopic techniques and screened for their in vitro antimicrobial activity against S. aureus, S. pyogenes, E. coli, P. aeruginosa, C. albicans, and A. niger. Most of the synthesized 1,3,4-oxadiazole derivatives exhibited moderate to good activity against the tested microbial strains.

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ACKNOWLEDGMENTS

The authors are thankful to the Principal, Maulana Azad College, Aurangabad, and the Principal, Swami Vivekanand College Mantha, for providing research facilities. We also thank SAIF Punjab University, Chandigarh, and SAIF Shillong for providing the spectral and analytical data.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Swami Vivekanand Senior College, 431504, Mantha, Maharashtra, India

    B. Dhotre

  2. Department of Chemistry, Lal Bahadur Shastri Senior College Partur, 431501, Jalna, Maharashtra, India

    R. Khalapure & S. Kotalwar

  3. J.E.S. College Jalna, 431203, Jalna, Maharashtra, India

    A. Shinde

  4. Kalikadevi Arts, Commerce, and Science College, 413249, Shirur Kasar, Maharashtra, India

    S. Sampal

  5. Department of Chemistry, Maulana Azad College, 431001, Aurangabad, Maharashtra, India

    P. M. Arif

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  1. B. Dhotre
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  2. R. Khalapure
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  3. A. Shinde
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  4. S. Sampal
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  5. S. Kotalwar
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Correspondence to B. Dhotre.

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Dhotre, B., Khalapure, R., Shinde, A. et al. Synthesis, Characterization, and Antimicrobial Evaluation of 2-Phenyl-5-{2-[3-(trifluoromethyl)phenyl]ethenyl}-1,3,4-oxadiazole Derivatives. Russ J Org Chem 59, 1813–1818 (2023). https://doi.org/10.1134/S1070428023100172

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