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Reaction of 2-Hydroxy-5-methylacetophenone Chalcones with Guanidine in the Presence of Hydrogen Peroxide

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Abstract

Two chalcones derived from 2-hydroxy-5-methylacetophenone reacted with guanidine in the presence of hydrogen peroxide to give 4,6-diaryl-2-aminopyrimidine or flavonol derivative, depending on the initial chalcone structure. The products were identified by NMR spectroscopy and X-ray analysis. Probable reaction paths were proposed.

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CONFLICT OF INTEREST

The authors declare the absence of conflict of interest.

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ACKNOWLEDGMENTS

The authors thank S.N. Babaeva for her help in per­forming experiments.

Funding

This work was supported by ongoing institutional funding. No additional grants to carry out or direct this particular research were obtained.

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Authors and Affiliations

  1. Faculty of Chemistry, Baku State University, 1148, Baku, Azerbaijan

    I. G. Mamedov

  2. Peoples’ Friendship University of Russia, 117198, Moscow, Russia

    V. N. Khrustalev

  3. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    V. N. Khrustalev

Authors
  1. I. G. Mamedov
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  2. V. N. Khrustalev
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Correspondence to I. G. Mamedov.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 9, pp. 1238–1242 https://doi.org/10.31857/S051474922309015X.

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Mamedov, I.G., Khrustalev, V.N. Reaction of 2-Hydroxy-5-methylacetophenone Chalcones with Guanidine in the Presence of Hydrogen Peroxide. Russ J Org Chem 59, 1637–1640 (2023). https://doi.org/10.1134/S1070428023090245

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