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Synthesis and Properties of a Water-Soluble Ureide Derived from Gаlodif and Succinic Acid

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Abstract

A new ureide has been synthesized by acylation of the anticonvulsant and anti-alcohol drug galodif N-[(3-chlorophenyl)(phenyl)methyl]urea with succinic anhydride in the presence of some acids. Unlike galodif which is almost insoluble in water, the synthesized ureide is soluble in aqueous media. It is expected to exhibit higher bioavailability and is promising as a liquid drug dosage form and a prodrug with prolonged action.

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CONFLICT OF INTEREST

The authors declare the absence of conflict of interest.

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Funding

This study was performed in the framework of state assignment of the Ministry of Science and Higher Education of the Russian Federation (project no. FSWW-2020-011).

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Authors and Affiliations

  1. Kizhner Research Center, Tomsk Polytechnic University, 634050, Tomsk, Russia

    V. Yu. Kuksenok, Y. Cui, V. V. Shtrykova & V. D. Filimonov

  2. Mental Health Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, 634014, Tomsk, Russia

    T. V. Shushpanova

Authors
  1. V. Yu. Kuksenok
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  2. Y. Cui
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  3. V. V. Shtrykova
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  4. V. D. Filimonov
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  5. T. V. Shushpanova
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Corresponding author

Correspondence to V. Yu. Kuksenok.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 9, pp. 1228–1232 https://doi.org/10.31857/S0514749223090136.

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Kuksenok, V.Y., Cui, Y., Shtrykova, V.V. et al. Synthesis and Properties of a Water-Soluble Ureide Derived from Gаlodif and Succinic Acid. Russ J Org Chem 59, 1629–1632 (2023). https://doi.org/10.1134/S1070428023090221

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  • DOI: https://doi.org/10.1134/S1070428023090221

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