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Direct Synthesis of Unsymmetrical 1,3-Butadiynes from Calcium Carbide and Aryl Iodides

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Abstract

A novel methodology for the one-pot synthesis of unsymmetrical 1,3-butadiynes directly by the reaction of calcium carbide with aryl iodides is reported. This reaction system uses a safe, inexpensive, and easily handled acetylene source, and is easy to manipulate. This protocol is not only highly productive and selective, but also tolerates a wide range of functional groups.

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The author gratefully acknowledges financial support from the Hebei Chemical & Pharmaceutical College.

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  1. Department of Chemical and Environmental Engineering, Hebei Chemical and Pharmaceutical College, 050026, Shijiazhuang, China

    Zhicai Zhao

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  1. Zhicai Zhao
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Correspondence to Zhicai Zhao.

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Zhao, Z. Direct Synthesis of Unsymmetrical 1,3-Butadiynes from Calcium Carbide and Aryl Iodides. Russ J Org Chem 59, 1436–1444 (2023). https://doi.org/10.1134/S1070428023080183

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