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Synthesis of 2-(Arylmethyl)benzazoles by the Sulfur-mediated Cyclization of 2-Aminophenol or 2-Aminoaniline with Arylacetylenes

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Abstract

2-(Arylmethyl)benzazoles have been prepared by the sulfur-mediated cyclization of 2-aminophenol or 2-aminoaniline with arylacetylenes in N-methylpiperidine in moderate-to-excellent yields on a gram scale.

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Funding

This work was supported by the National Key Research and Development Program of China (2019YFC1906603), Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (XTC1806), National Natural Science Foundation of China (grant no. 22078152), and Six Talent Peaks Project in Jiangsu Province (SWYY-030/SWYY-118).

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Authors and Affiliations

  1. College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 211816, Nanjing, China

    P. P. Ma, H. L. Wu & H. F. Gan

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  1. P. P. Ma
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  2. H. L. Wu
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Correspondence to H. F. Gan.

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Ma, P.P., Wu, H.L. & Gan, H.F. Synthesis of 2-(Arylmethyl)benzazoles by the Sulfur-mediated Cyclization of 2-Aminophenol or 2-Aminoaniline with Arylacetylenes. Russ J Org Chem 59, 1424–1435 (2023). https://doi.org/10.1134/S1070428023080171

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