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Microwave-assisted One-pot, Catalyst-free Synthesis of Novel 9H-[1,3]dioxolo[4,5-f]chromene Derivatives

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Abstract

A new one-pot three-component reaction for the synthesis of 9H-[1,3]dioxolo[4,5-f]chromene derivatives has been developed. The synthesis was achieved by reacting sesamol, aromatic aldehydes and (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine under microwave irradiation. This transformation involves the formation of a chromene ring by creating two C–C bonds and one C–O bond in a single synthetic operation. This rapid one-pot reaction does not require a catalyst. It is solvent-free, avoids chromatographic purification, and provides good yields.

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ACKNOWLEDGMENTS

We are highly indebted to the authorities of the GITAM University for providing financial support for this work and grateful to the Department of Chemistry, GITAM School of Science, Hyderabad, for providing laboratory facilities.

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Authors and Affiliations

  1. Department of Chemistry GITAM School of Science, GITAM (Deemed to be University), 502329, Hyderabad, India

    Raghavendar Avula, H. Sharath Babu & Muvvala Venkatanarayana

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  1. Raghavendar Avula
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  2. H. Sharath Babu
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  3. Muvvala Venkatanarayana
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Correspondence to H. Sharath Babu.

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Avula, R., Babu, H.S. & Venkatanarayana, M. Microwave-assisted One-pot, Catalyst-free Synthesis of Novel 9H-[1,3]dioxolo[4,5-f]chromene Derivatives. Russ J Org Chem 59, 1417–1423 (2023). https://doi.org/10.1134/S107042802308016X

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