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Ultrasound-Assisted Synthesis of Benzimidazole Derivatives: A Catalyst-Free Green Chemistry Approach

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Abstract

A green and effective catalyst-free ultrasound-assisted synthetic methodology for benzimidazole derivatives has been developed. A total of fifteen derivatives have been prepared through sonochemistry, which needed shorter reaction times for completion (8–30 min) and occurred in high yields (92–95%). The synthesized benzimidazole derivatives were identified by comparing their physicochemical and spectral characteristics with the respective published data for the authentic samples.

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Authors and Affiliations

  1. Ramanbhai Patel College of Pharmacy, Charotar University of Science and Technology, CHARUSAT Campus, 388421, Changa, India

    Drashti Shah, Ashish Patel, Stuti Patel, Meshwa Mehta & Yug Patel

  2. Piramal Pharma, Pharmaceutical Special Economic Zone, 382213, Ahmedabad, India

    Bhargav Bhimani

  3. North Carolina State University, 27695, Raleigh, USA

    Tushar Bambharoliya

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  1. Drashti Shah
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  2. Ashish Patel
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Shah, D., Patel, A., Patel, S. et al. Ultrasound-Assisted Synthesis of Benzimidazole Derivatives: A Catalyst-Free Green Chemistry Approach. Russ J Org Chem 59, 1397–1406 (2023). https://doi.org/10.1134/S1070428023080146

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