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Four-Component Condensation of Ethyl Acetoacetate, Phenylglyoxal Hydrate, Barbituric Acid, and Primary Amines

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Abstract

The four-component condensation of ethyl acetoacetate, phenylglyoxal hydrate, barbituric acid, and primary amines was used to obtain polysubstituted pyrroles containing a barbituric acid fragment. In some cases, by-products formed by the three-component condensation of phenylglyoxal hydrate, barbituric acid, and amines were isolated.

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Far Eastern Federal University, 690922, Vladivostok, Russia

    A. N. Andin & A. V. Kukharev

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  1. A. N. Andin
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  2. A. V. Kukharev
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Correspondence to A. N. Andin.

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Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 8, pp. 1050–1056 https://doi.org/10.31857/S0514749223080062.

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Andin, A.N., Kukharev, A.V. Four-Component Condensation of Ethyl Acetoacetate, Phenylglyoxal Hydrate, Barbituric Acid, and Primary Amines. Russ J Org Chem 59, 1329–1334 (2023). https://doi.org/10.1134/S1070428023080067

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  • DOI: https://doi.org/10.1134/S1070428023080067

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