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Electrochemical Aspect of the Synthesis of 2-Nitroethanol-Based Heteroarchitecture

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Abstract

The compatibility of several functional groups appeared much tapered in classical coupling organic reaction due to the use of strong bases, organic solvents, and reagents. Therefore, an innovative electrochemical strategy of activating an acidic hydrogen in the ethanol/lithium perchlorate system has been described to accomplish the criteria of ecological footprint for the synthesis of 2-nitroethanol-based heteroarchitecture. This innovative protocol is simple and clean, and it sets the stage for designing molecular hydrogen via in situ electrogenerated base (EGBS). After screening different solvents, it has been found that the ethanol/lithium perchlorate electrolyte system has unleashed power that indirectly activates an acidic hydrogen in an active methylene compound. For clarity, a concise study has been performed on dissociation constant value and its effect on redox potential that is stimulated indirectly through electrical input. This tactic offers several advantages such as a cleaner reaction profile, shorter reaction time, simple workup procedure, and excellent yield.

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  1. Department of Chemistry, R.B. College, Dalsingsarai (A Constituent Unit of Lalit Narayan Mithila University, Darbhanga), 848114, Samastipur, Bihar, India

    A. Saraswat

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Saraswat, A. Electrochemical Aspect of the Synthesis of 2-Nitroethanol-Based Heteroarchitecture. Russ J Org Chem 59, 1041–1047 (2023). https://doi.org/10.1134/S1070428023060118

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