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Synthesis and Antimicrobial Activity of Novel (1-Aryl-1H-1,2,3-triazol-4-yl)methyl 3-Acetamido-1-phenyl-1H-benzo[f]chromene-2-carboxylates

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Abstract

A series of novel (1-aryl-1H-1,2,3-triazol-4-yl)methyl 3-acetamido-1-phenyl-1H-benzo[f]chromene-2-carboxylates were synthesized from prop-2-yn-1-yl 3-acetamido-1-phenyl-1H-benzo[f]chromene-2-carbox­ylate. 3-Amino-1-phenyl-1H-benzo[f]chromene-2-carbonitrile and 2-amino-4-phenyl-4a,5,6,7,8,8a-hexahydro-4H-chromene-3-carbonitrile were prepared by three-component condensation of benzaldehyde, β-naphthol or cyclohexanol, and malononitrile. The synthesized compounds were evaluated for their antibacterial and anti­fungal activities in comparison to chloramphenicol and amphotericin B as reference antibiotics.

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ACKNOWLEDGMENTS

The authors thank the Director of the Indian Institute of Chemical Technology (Hyderabad), Chaitanya Deemed to be University (Hanumakonda), Vaagdevi Degree and PG College, Department of Microbiology (Hanumakonda) for providing spectral and biological activity data.

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Authors and Affiliations

  1. Department of Chemistry, Chaitanya Deemed to be University, 506001, Hanumakonda, Telangana, India

    S. Shamili & S. Kavitha

  2. Department of Microbiology, Vaagdevi Degree and PG College, 506001, Hanumakonda, Telangana, India

    G. Chandrakala & Sd. I. Farheen

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  1. S. Shamili
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  2. G. Chandrakala
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  3. Sd. I. Farheen
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  4. S. Kavitha
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Correspondence to S. Kavitha.

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Shamili, S., Chandrakala, G., Farheen, S.I. et al. Synthesis and Antimicrobial Activity of Novel (1-Aryl-1H-1,2,3-triazol-4-yl)methyl 3-Acetamido-1-phenyl-1H-benzo[f]chromene-2-carboxylates. Russ J Org Chem 59, 1033–1040 (2023). https://doi.org/10.1134/S1070428023060106

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