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Recyclization of 5-Substituted 4-(2,2,2-Trichloroacetyl)furan-2,3-diones with (Het)Arenecarbohydrazides

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Abstract

The reaction of 5-substituted 4-(2,2,2-trichloroacetyl)furan-2,3-diones with substituted benzohydra­zides, thiophene-2-carbohydrazide, or 2-phenylacetohydrazide in anhydrous chloroform on stirring for several hours afforded 1-substituted 3-aryl(heteroaryl)-5-hydroxy-4-(2,2,2-trichloroacetyl)-4,5-dihydro-1H-pyrazole5-carboxylic acids as mixtures of two diastereoisomers at a ratio of about 70:30.

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Fig. 1.
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Funding

This study was financially supported by the world-level Perm Scientific and Educational Center “Rational Use of the Earth Interior,” 2023.

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Authors and Affiliations

  1. Perm State University, 614990, Perm, Russia

    S. S. Kharitonova, E. R. Nasibullina, D. V. Ivanov & N. Yu. Lisovenko

Authors
  1. S. S. Kharitonova
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  2. E. R. Nasibullina
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  3. D. V. Ivanov
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  4. N. Yu. Lisovenko
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Correspondence to N. Yu. Lisovenko.

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Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 6, pp. 762–771 https://doi.org/10.31857/S0514749223060046.

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Kharitonova, S.S., Nasibullina, E.R., Ivanov, D.V. et al. Recyclization of 5-Substituted 4-(2,2,2-Trichloroacetyl)furan-2,3-diones with (Het)Arenecarbohydrazides. Russ J Org Chem 59, 993–999 (2023). https://doi.org/10.1134/S1070428023060040

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