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One-Pot Synthesis of 3-Carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic Acids

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Abstract

A one-pot synthesis of 3-carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic acids has been developed via the reaction of 4-oxoalkane-1,1,2,2-tetracarbonitriles with water, followed by alkaline hydrolysis of the resulting mixture of 2-oxo-1,2-dihydropyridine-3,4-dicarbonitrile and 2-oxo-4-cyano-1,2-dihydropyri­dine-3-carboxamide.

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Funding

This study was financially supported by the President of the Russian Federation in the framework of scholarship for young scientists and post-graduate students (project no. SP-2768.2022.4).

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Authors and Affiliations

  1. I.N. Ul’yanov Chuvash State University, 428015, Cheboksary, Russia

    S. V. Fedoseev, K. V. Lipin & O. V. Ershov

Authors
  1. S. V. Fedoseev
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  2. K. V. Lipin
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  3. O. V. Ershov
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Corresponding author

Correspondence to S. V. Fedoseev.

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The authors declare the absence of conflict of interest.

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Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 3, pp. 400–404 https://doi.org/10.31857/S0514749223030114.

Dedicated to Full Member of the Russian Academy of Sciences I.P. Beletskaya on her jubilee.

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Fedoseev, S.V., Lipin, K.V. & Ershov, O.V. One-Pot Synthesis of 3-Carbamoyl-2-oxo-1,2-dihydropyridine-4-carboxylic Acids. Russ J Org Chem 59, 536–539 (2023). https://doi.org/10.1134/S1070428023030223

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  • DOI: https://doi.org/10.1134/S1070428023030223

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