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Synthesis and Aminomethylation of A-Azepane-Fused Uvaol and Betulin Derivatives

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Abstract

Stepwise conjugation of biologically active A-azepanobetulin and A-azepanouvaol with succinic anhydride and propargylamine, followed by copper-catalyzed Mannich reaction, afforded new hybrid com­pounds containing an N-methylpiperazine fragment with an average yield of 73%. The product structure was determined by NMR spectroscopy.

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ACKNOWLEDGMENTS

The NMR spectra were recorded using the facilities of the Chemistry joint center (Ufa Institute of Chemistry, Russian Academy of Sciences) and Agidel regional joint center (Ufa Federal Research Center, Russian Academy of Sciences).

Funding

This study was financially supported in the framework of state assignment no. 1021062311390-1-1.4.1.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences, 450054, Ufa, Russia

    A. V. Petrova

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  1. A. V. Petrova
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Correspondence to A. V. Petrova.

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The author declares the absence of conflict of interest.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2023, Vol. 59, No. 1, pp. 133–138 https://doi.org/10.31857/S0514749223010123.

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Petrova, A.V. Synthesis and Aminomethylation of A-Azepane-Fused Uvaol and Betulin Derivatives. Russ J Org Chem 59, 202–206 (2023). https://doi.org/10.1134/S1070428023010232

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  • DOI: https://doi.org/10.1134/S1070428023010232

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