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Design and Straightforward Synthesis of Novel N-substituted 6-Fluoro-3-(piperidin-4-yl)-1,2-benzoxazole Derivatives and Their Antibacterial Activity

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Abstract

A facile synthetic route to N-substituted 6-fluoro-3-(piperidin-4-yl)-1,2-benzoxazole derivatives using piperidine-4-carboxylic acid, 1,3-difluorobenzene, and various halogen derivatives has been described. The target products were obtained with 55–92% yields in relatively short reaction times. The structure of the synthesized compounds was confirmed by 1H and 13C NMR and mass spectra. Antibacterial evaluation by the agar well diffusion method revealed that only one of the compounds showed antibacterial effect against Staphylococcus aureus (MTCC 3160) at a concentration of 50 μg per well.

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Authors and Affiliations

  1. Division of Chemistry, Department of Sciences and Humanities, Vignan’s Foundation for Science, Technology, and Research, 522213, Vadlamudi, Guntur, India

    Krishna Kanth Garlapati & N. Srinivasu

  2. Department of Chemistry, GSS, GITAM (Deemed to be University), 530045, Visakhapatnam, India

    Ravi Kumar Ganta

  3. Department of Biotechnology, GSS, GITAM (Deemed to be University), 530045, Visakhapatnam, India

    K. Siva Kumar

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  1. Krishna Kanth Garlapati
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  2. Ravi Kumar Ganta
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  3. K. Siva Kumar
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  4. N. Srinivasu
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Correspondence to Krishna Kanth Garlapati or N. Srinivasu.

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Garlapati, K.K., Ganta, R.K., Kumar, K.S. et al. Design and Straightforward Synthesis of Novel N-substituted 6-Fluoro-3-(piperidin-4-yl)-1,2-benzoxazole Derivatives and Their Antibacterial Activity. Russ J Org Chem 59, 190–195 (2023). https://doi.org/10.1134/S1070428023010219

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  • DOI: https://doi.org/10.1134/S1070428023010219

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