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Synthesis of Substituted Quinolines through Bismuth-Catalyzed Cyclization

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Abstract

The synthesis of quinoline derivatives through bismuth-catalyzed cyclization of phenylacetylene with ethyl 2-(arylimino)acetates has been reported. The excellence of this method is that the reaction is carried out at room temperature, and the catalyst is exceptionally productive, low toxic, and very cheap. The mild reaction conditions added an extraordinary benefit and made it attractive in economic and environmental aspects. The target products were isolated in up to 89% yield.

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ACKNOWLEDGMENTS

The authors thank the Central Instrumentation Facility (CIF, Pondicherry University) for the NMR spectroscopic facility and DST-FIST for the ESI-MS and single-crystal XRD facility. M.A.B.R. acknowledges Pondicherry University for providing University Research Fellowship.

Funding

T.S. thanks the Science and Engineering Research Board, Government of India, for financial support (file no. EEQ/2018/000428).

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Authors and Affiliations

  1. Department of Chemistry, Pondicherry University, R.V. Nagar, 605014, Kalapet, Puducherry, India

    M. A. B. Riyaz, L. C. Nimbus & T. Swu

  2. CMR Institute of Technology, Kandlakoya Village, 501401, Hyderabad, Telangana, India

    B. Rajasekhar

Authors
  1. M. A. B. Riyaz
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  2. L. C. Nimbus
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  3. B. Rajasekhar
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  4. T. Swu
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Correspondence to T. Swu.

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Riyaz, M.A.B., Nimbus, L.C., Rajasekhar, B. et al. Synthesis of Substituted Quinolines through Bismuth-Catalyzed Cyclization. Russ J Org Chem 59, 150–157 (2023). https://doi.org/10.1134/S1070428023010165

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  • DOI: https://doi.org/10.1134/S1070428023010165

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