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Design, Synthesis, and In Vitro Anticancer Activity of Triazolyl Analogs of Abietic Acid

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Abstract

A series of abietic acid analogs modified with a triazole moiety were synthesized using Huisgen 1,3-dipolar cycloaddition in order to obtain potent antitumor agents. The synthesized compounds and starting materials were tested in vitro against four human cancer cell lines, MDA-MB-231 and MCF-7 (human breast cancer cells), A549 (human lung cancer), PC3 (human prostate cancer), and FR2 (non-tumor human breast epithelial cell line) by MTT assay. Some of the synthesized analogs showed better biological profiles than that of the precursors. The most active compound (4-hydroxyphenyl derivative) showed an IC50 value of 35.4 µM against MDA-MB-231 cancer cell line.

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Fig. 1.
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  1. National Institute of Technology Hazratbal, 190006, Srinagar, Jammu & Kashmir, India

    G. Ali & T. Ara

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Ali, G., Ara, T. Design, Synthesis, and In Vitro Anticancer Activity of Triazolyl Analogs of Abietic Acid. Russ J Org Chem 59, 142–149 (2023). https://doi.org/10.1134/S1070428023010153

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