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Synthesis of New Cyclohexenone Derivatives Using Potassium Phthalimide as a Green Organocatalyst. One-Pot Microwave-Assisted Synthesis and Antimicrobial Evaluation

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Abstract

A direct one-pot three-component reaction of 4-acetyl-N-benzylbenzamide, ethyl acetoacetate or methyl acetoacetate, and aromatic aldehydes under microwave irradiation afforded a series of new cyclo­hexenone derivatives. The proposed procedure has the advantages of one-pot reaction, high efficiency, short reaction time, and simple workup. The antimicrobial activity of the obtained cyclohexenone derivatives was tested against a variety of bacteria (E. coli, S. aureus, S. pyogenes, P. aeruginosa) and fungi (C. albicans, A. niger, A. clavatus).

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ACKNOWLEDGMENTS

The authors are thankful to the Department of Chemistry, RK University, for providing laboratory facilities for research work.

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Authors and Affiliations

  1. Department of Chemistry, School of Sciences, RK University, Kasturbadham, 360020, Rajkot, Gujarat, India

    S. P. Odiya, S. P. Das & J. J. Boruah

  2. Department of Chemistry, University Institute of Science, Chandigarh University, 140413, Mohali, Punjab, India

    S. P. Das

  3. Microcare Laboratory and Tuberculosis Research Center, 395003, Surat, Gujarat, India

    D. P. Rajani

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Odiya, S.P., Das, S.P., Boruah, J.J. et al. Synthesis of New Cyclohexenone Derivatives Using Potassium Phthalimide as a Green Organocatalyst. One-Pot Microwave-Assisted Synthesis and Antimicrobial Evaluation. Russ J Org Chem 59, 117–132 (2023). https://doi.org/10.1134/S107042802301013X

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