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Synthesis and Properties of Symmetrical Bis-ureas Containing a 4-(Trifluoromethoxy)phenyl Fragment

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Abstract

A series of N,N′-disubstituted bis-ureas containing a lipophilic 4-(trifluoromethoxy)phenyl fragment were synthesized in 58–80% yields by reaction of 4-(trifluoromethoxy)phenyl isocyanate with aliphatic diamines. The synthesized compounds are promising as inhibitors of human soluble epoxide hydrolase.

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Funding

This study was performed under financial support by the Russian Science Foundation (project no. 19-73-10002).

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Authors and Affiliations

  1. Volgograd State Technical University, 400005, Volgograd, Russia

    Ya. P. Kuznetsov, V. V. Burmistrov & G. M. Butov

  2. Volzhsky Polytechnic Institute (Branch), Volgograd State Technical University, 404121, Volzhsky, Russia

    G. M. Butov

Authors
  1. Ya. P. Kuznetsov
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  2. V. V. Burmistrov
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  3. G. M. Butov
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Corresponding author

Correspondence to G. M. Butov.

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The authors declare the absence of conflict of interest.

Additional information

Translated from Zhurnal Organicheskoi Khimii, 2022, Vol. 58, No. 10, pp. 1096–1102 https://doi.org/10.31857/S051474922210007X.

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Kuznetsov, Y.P., Burmistrov, V.V. & Butov, G.M. Synthesis and Properties of Symmetrical Bis-ureas Containing a 4-(Trifluoromethoxy)phenyl Fragment. Russ J Org Chem 58, 1429–1433 (2022). https://doi.org/10.1134/S1070428022100074

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  • DOI: https://doi.org/10.1134/S1070428022100074

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