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Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones, -thione, and -selones, Catalyzed by TiO2 Nanoparticles

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Abstract

The synthesis of 3,4-dihydropyrimidin-2(1H)-one, -thione, and -selone derivatives by three-com­ponent condensation of aromatic aldehydes, ethyl acetoacetate, and urea (thiourea, selenourea) was catalyzed by TiO2 nanoparticles. The effect of this catalyst on the reaction time and yield was investigated. The use of TiO2 nanoparticles improved the reaction conditions to an acceptable level, and good yields of the products were obtained.

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Authors and Affiliations

  1. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    B. Mohammadi, F. K. Behbahani, G. B. Marandi & B. Mirza

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  1. B. Mohammadi
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  2. F. K. Behbahani
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  3. G. B. Marandi
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Correspondence to F. K. Behbahani.

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Mohammadi, B., Behbahani, F.K., Marandi, G.B. et al. Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones, -thione, and -selones, Catalyzed by TiO2 Nanoparticles. Russ J Org Chem 58, 1319–1326 (2022). https://doi.org/10.1134/S1070428022090184

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