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Solvent-Free Synthesis of 2-[(Di)aminophenyl]-1,3,4-oxadiazoles

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Abstract

An efficient procedure has been developed for the synthesis of 2-phenyl-1,3,4-oxadiazole deriva­tives with one or two pyrrolidin-1-yl substituents in the benzene ring via nucleophilic substitution of fluorine in 2-[(di)fluorophenyl]-1,3,4-oxadiazole on heating with pyrrolidine under solvent-free conditions.

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Funding

This study was performed under financial support by the Russian Science Foundation (project no. 18-73-10119-P).

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Authors and Affiliations

  1. Yeltsin Ural Federal University, 620002, Yekaterinburg, Russia

    A. P. Krinochkin, Ya. K. Shtaitz, M. I. Savchuk, D. S. Kopchuk, N. V. Slovesnova, I. S. Kovalev, E. V. Nosova, G. V. Zyryanov & O. N. Chupakhin

  2. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences, 620219, Yekaterinburg, Russia

    A. P. Krinochkin, M. I. Savchuk, D. S. Kopchuk, N. V. Slovesnova, E. V. Nosova, G. V. Zyryanov & O. N. Chupakhin

  3. Ural Medical University, Ministry of Health of the Russian Federation, 620028, Yekaterinburg, Russia

    N. V. Slovesnova

Authors
  1. A. P. Krinochkin
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  2. Ya. K. Shtaitz
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  3. M. I. Savchuk
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  4. D. S. Kopchuk
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  5. N. V. Slovesnova
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  6. I. S. Kovalev
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  7. E. V. Nosova
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  8. G. V. Zyryanov
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  9. O. N. Chupakhin
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Corresponding author

Correspondence to G. V. Zyryanov.

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Additional information

Translated from Zhurnal Organicheskoi Khimii, 2022, Vol. 58, No. 7, pp. 767–770 https://doi.org/10.31857/S0514749222070102.

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Krinochkin, A.P., Shtaitz, Y.K., Savchuk, M.I. et al. Solvent-Free Synthesis of 2-[(Di)aminophenyl]-1,3,4-oxadiazoles. Russ J Org Chem 58, 1064–1066 (2022). https://doi.org/10.1134/S1070428022070181

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  • DOI: https://doi.org/10.1134/S1070428022070181

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