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Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation

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Abstract

A simple, efficient, and green protocol has been developed for the synthesis of 2-amino-4-aryl-4H-chromene-3-carbonitriles via a one-pot three-component condensation of resorcinol, malononitrile, and substi­tuted aromatic aldehydes in ethanol under reflux using InCl3 as a catalyst. This methodology has a number of advantages such as the use of a very small amount of catalyst, easy access, short reaction time, easy workup, high yields, and nontoxicity of the catalyst and solvent.

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ACKNOWLEDGMENTS

The authors are grateful to Principal, Yeshwant Mahavidyalaya, Nanded, for providing laboratory facilities, UGC, New Delhi (File no.41-230/2012) (SR) for financial support, and The Director, Punjab University, Chandigarh for providing spectra.

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Authors and Affiliations

  1. Department of Chemistry, Sant Dnyaneshwar Mahavidyalaya, Soegaon, 431120, Aurangabad, Maharashtra, India

    S. S. Choudhare & M. Chopade

  2. Department of Chemistry, Yeshwant Mahavidyalaya, 431602, Nanded, Maharashtra, India

    V. N. Bhosale

Authors
  1. S. S. Choudhare
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  2. V. N. Bhosale
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  3. M. Chopade
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Correspondence to S. S. Choudhare or M. Chopade.

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Choudhare, S.S., Bhosale, V.N. & Chopade, M. Synthesis of 2-Amino-4H-chromene Derivatives Using InCl3 and Their Antimicrobial Evaluation. Russ J Org Chem 58, 913–916 (2022). https://doi.org/10.1134/S1070428022060227

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  • DOI: https://doi.org/10.1134/S1070428022060227

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