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Synthesis, Characterization, and Molecular Docking Study of N-[4-(1H-Benzimidazol-2-yl)-1,3-thiazol-2-yl]-1-[(E)-phenyldiazenyl)-1-phenylmethanimines

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Abstract

A series of new benzamidine derivatives have been synthesized in good yields by involving 1-(1H-benzimidazol-2-yl)-2-bromoethanone, 4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-amine, and N-benzyli­dene-4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-amine as reactive intermediates. The synthesized compounds were characterized by spectral data. Molecular docking study of N-(4-(1H-benzimidazol-2-yl)-1,3-thiazol-2-yl]-1-[(E)-phenyldiazenyl]-1-phenylmethanimine has been carried out as a representative case.

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ACKNOWLEDGMENTS

The authors thank Jawaharlal Nehru Technological University, Hyderabad, India, for providing necessary facilities to carry out this work.

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Authors and Affiliations

  1. Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, 500085, Hyderabad, India

    S. Ramakrishna Reddy, G. Ganga Reddy & Ch. Venkata Ramana Reddy

  2. Sreenidhi Institute of Science and Technology, Yamnampet, Ghatkesar, 501301, Hyderabad, India

    E. Laxminarayana

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  1. S. Ramakrishna Reddy
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  2. G. Ganga Reddy
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  3. Ch. Venkata Ramana Reddy
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Correspondence to Ch. Venkata Ramana Reddy.

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Reddy, S.R., Reddy, G.G., Reddy, C.V.R. et al. Synthesis, Characterization, and Molecular Docking Study of N-[4-(1H-Benzimidazol-2-yl)-1,3-thiazol-2-yl]-1-[(E)-phenyldiazenyl)-1-phenylmethanimines. Russ J Org Chem 58, 858–864 (2022). https://doi.org/10.1134/S107042802206015X

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