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Enantioselective Aldol Reaction between Isatins and Ketones, Catalyzed by Chiral Norephedrine-Derived β-Amino Alcohols with a Thiophene Moiety

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Abstract

Chiral norephedrine-based β-amino alcohol bearing a substituted thiophene ring were applied as catalysts for the enantioselective aldol reaction of isatins with ketones. Using enantiomeric chiral amino alco­hols, the desired aldol products were obtained in high yields and excellent enantioselectivities (up to 95% ee) under optimized conditions.

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  1. Department of Chemistry, Arts and Science Faculty, Hatay Mustafa Kemal University, 31040, Hatay, Turkey

    A. E. Aydin

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Aydin, A.E. Enantioselective Aldol Reaction between Isatins and Ketones, Catalyzed by Chiral Norephedrine-Derived β-Amino Alcohols with a Thiophene Moiety. Russ J Org Chem 58, 820–829 (2022). https://doi.org/10.1134/S1070428022060100

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