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New Synthesis of Tetrahydroisoquinolines

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Abstract

The reaction of cyclohexylidenecyanothioacetamide with N,N-dimethylformamide dimethyl acetal was studied. This transformation, depending on the reaction conditions, leads to different results: when the starting reagents are refluxed without a solvent, 3-(methylsulfanyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile is formed, and refluxing in benzene leads to 2-cyano-3-(dimethylamino)prop-2-enethioamide. The structure of these products was studied by XRD analysts.

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Authors and Affiliations

  1. Lugansk State Pedagogical University, 91011, Lugansk, Ukraine

    I. V. Dyachenko & V. D. Dyachenko

  2. Kurchatov Institute National Research Center, 123182, Moscow, Russia

    P. V. Dorovatovskii

  3. Peoples’ Friendship University of Russia (RUDN University), 117198, Moscow, Russia

    V. N. Khrustalev

  4. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, 119991, Moscow, Russia

    V. N. Khrustalev

  5. Lomonosov Moscow State University, 119991, Moscow, Russia

    V. G. Nenajdenko

Authors
  1. I. V. Dyachenko
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  2. V. D. Dyachenko
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  3. P. V. Dorovatovskii
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  4. V. N. Khrustalev
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  5. V. G. Nenajdenko
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Correspondence to V. G. Nenajdenko.

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Translated from Zhurnal Organicheskoi Khimii, 2022, Vol. 58, No. 5, pp. 469–475 https://doi.org/10.31857/S0514749222050032.

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Dyachenko, I.V., Dyachenko, V.D., Dorovatovskii, P.V. et al. New Synthesis of Tetrahydroisoquinolines. Russ J Org Chem 58, 657–662 (2022). https://doi.org/10.1134/S1070428022050037

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