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Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents

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Abstract

A new series of 4-(1H-imidazol-4-yl)-2-(substituted phenyl)-1,4-dihydrobenzo[4,5]imidazo[1,2-a]­pyrimidines have been synthesized via a one-pot reaction using PEG-400 as a green solvent in the first step and butan-1-ol in the second step. The structures of the synthesized compounds have been confirmed by spectral data, including IR, 1H and 13C NMR and mass spectra, and their in vitro antimicrobial and antitubercular activities have been evaluated.

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ACKNOWLEDGMENTS

The authors are thankful to the Department of Chemistry, Saurashtra University and NFDD, Rajkot, for providing the necessary facilities to carry out this study.

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Authors and Affiliations

  1. Department of Chemistry, Government Science College, 364505, Gariyadhar, Gujarat, India

    N. M. Panchani

  2. Department of Chemistry, Saurashtra University, 360005, Rajkot, Gujarat, India

    H. S. Joshi

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  1. N. M. Panchani
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  2. H. S. Joshi
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Correspondence to H. S. Joshi.

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Panchani, N.M., Joshi, H.S. Green and Catalyst-Free Synthesis of Some New Benzo[4,5]imidazo[1,2-a]pyrimidine Derivatives as Antimicrobial and Antitubercular Agents. Russ J Org Chem 58, 604–611 (2022). https://doi.org/10.1134/S1070428022040200

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