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Synthesis and Cytotoxicity Screening of Some Novel 1-Substituted 2-Oxo-1H-quinoline-3-carboxylic Acid Derivatives against Breast Carcinoma Cell Line

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Abstract

The quinolinone structure is an attractive scaffold for drug discovery research. Quinolinones are valuable as therapeutic agents for various diseases. A series of novel 1-substituted 8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid derivatives have been synthesized via the addition of ethyl 3-aryl-2-cyanoacrylates to 8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid and 5-bromo-8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid. The subsequent condensation with hydrazine hydrate afforded the corresponding 5-aminodihydropyrazol-3-one derivatives bearing a quinolinone moiety. The structure of the synthesized compounds was confirmed by spectroscopic methods and elemental analyses. Some 1-substituted 8-methoxy-2-oxo-1H-quinoline-3-carbox­ylic acid derivatives were evaluated in vitro against MCF-7 breast cancer cell line.

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Funding

This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-Track Research Funding Program.

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  1. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, 11671, Riyadh, Saudi Arabia

    G. H. Al-Hazmi

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  1. G. H. Al-Hazmi
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Correspondence to G. H. Al-Hazmi.

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Al-Hazmi, G.H. Synthesis and Cytotoxicity Screening of Some Novel 1-Substituted 2-Oxo-1H-quinoline-3-carboxylic Acid Derivatives against Breast Carcinoma Cell Line. Russ J Org Chem 58, 433–438 (2022). https://doi.org/10.1134/S1070428022030241

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  • DOI: https://doi.org/10.1134/S1070428022030241

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