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Synthesis of Novel Amide-Functionalized Imidazo[1,2-a]pyrimidin-5(1H)-ones and Their Biological Evaluation as Anticancer Agents

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Abstract

A series of novel amide-functionalized imidazo[1,2-a]pyrimidin-5(1H)-ones were synthesized by propargylation of the key intermediate 2-amino-6-(trifluoromethyl)pyrimidin-4(3H)-one, followed by cycliza­tion and amide functionalization. All synthesized compounds were evaluated for their anticancer activity against different human cancer cell lines, and most of them showed a good activity. In particular, pyrrolidine-derived imidazo[1,2-a]pyrimidine showed excellent anticancer activity against HeLa cell line.

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ACKNOWLEDGMENTS

The authors are grateful to the department of research and development, Dr. JCR Bio-Sciences Private Limited, for the support.

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Authors and Affiliations

  1. Department of Chemistry, College of Engineering, Jawaharlal Nehru Technological University, 500085, Hyderabad, India

    S. Annareddygari

  2. Department of Research and Development, Dr. JCR Bio-Sciences Private Limited, 500039, Hyderabad, India

    S. Annareddygari, V. Kasireddy & J. Reddy

  3. Department of Chemistry, CMR Engineering College, Jawaharlal Nehru Technological University, 501401, Hyderabad, India

    V. Kasireddy

Authors
  1. S. Annareddygari
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  2. V. Kasireddy
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  3. J. Reddy
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Correspondence to S. Annareddygari.

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Annareddygari, S., Kasireddy, V. & Reddy, J. Synthesis of Novel Amide-Functionalized Imidazo[1,2-a]pyrimidin-5(1H)-ones and Their Biological Evaluation as Anticancer Agents. Russ J Org Chem 58, 412–418 (2022). https://doi.org/10.1134/S1070428022030216

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  • DOI: https://doi.org/10.1134/S1070428022030216

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