Abstract
A rapid and efficient protocol has been proposed for the synthesis of 7-(4-substituted benzylidene)-3-(4-substituted phenyl)-3,3a,4,5,6,7-hexahydro-2H-indazoles under microwave irradiation. The synthesized compounds were screened for anticancer activity against 60 human cancer cell lines, and some of them exhibited significant anticancer activity against leukemia and colon cancer cell lines.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
REFERENCES
Dhaduk, B.B., Patel, C.B., and Parsania, P.H., Lett. Drug Des. Discovery, 2015, vol. 12, p. 152. https://doi.org/10.2174/1570180811666140915222545
Patel, C.B., Dhaduk, B.B., and Parsania, P.H., Lett. Drug Des. Discovery, 2015, vol. 12, p. 505. https://doi.org/10.2174/1570180812666141224211602
Lalpara, J.N., Vachhani, M.D., Hadiyal, S.D., Goswami, S., and Dubal, G.G., Russ. J. Org. Chem., 2021, vol. 57, p. 241. https://doi.org/10.1134/S1070428021020159
Radia, A.J., Lalpara, J.N., Modasiya, I.J., and Dubal, G.G., J. Heterocycl. Chem., 2021, vol. 58, p. 612. https://doi.org/10.1002/jhet.4200
Lalpara, J.N., Hadiyal, S.D., Dhalani, J.M., and Dubal, G.G., Eur. Chem. Bull., 2021, vol. 10, p. 139. https://doi.org/10.17628/ecb.2021.10.139-146
Lalpara, J.N., Hadiyal, S.D., Radia, A.J., Dhalani, J.M., and Dubal, G.G., Polycyclic Aromat. Compd., 2020. https://doi.org/10.1080/10406638.2020.1852586
Hadiyal, S.D., Lalpara, J.N., Parmar, N.D., and Joshi, H.S., Polycyclic Aromat. Compd., 2021. https://doi.org/10.1080/10406638.2021.1913425
Hadiyal, S.D., Parmar, N.D., Kalavadiya, P.L., Lalpara, J.N., and Joshi, H.S., Russ. J. Org. Chem., 2020, vol. 56, p. 671. https://doi.org/10.1134/S1070428020040168
Began, G., Sudharshan, E., Udaya Sankar, K., and Appu Rao, A.G., J. Agric. Food Chem., 1999, vol. 47, p. 4992. https://doi.org/10.1021/jf9900837
Iqbal, M., Sharma, S.D., Okazaki, Y., Fujisawa, M., and Okada, S., Pharmacol. Toxicol., 2003, vol. 92, p. 33. https://doi.org/10.1034/j.1600-0773.2003.920106.x
Yadav, V.S., Mishra, K.P., Singh, D.P., Mehrotra, S., and Singh, V.K., Immunopharmacol. Immunotoxicol., 2005, vol. 27, p. 485. https://doi.org/10.1080/08923970500242244
Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., and Morales, N.P., Biol. Pharm. Bull., 2007, vol. 30, p. 74. https://doi.org/10.1248/bpb.30.74
Kawamori, T., Lubet, R., Steele, V.E., Kelloff, G.J., Kaskey, R.B., Rao, C.V., and Reddy, B.S., Cancer Res., 1999, vol. 59, p. 597. PMID: 9973206
Boyd, M.R. and Paull, K.D., Drug Dev. Res., 1995, vol. 34, p. 91. https://doi.org/10.1002/ddr.430340203
Paull, K.D., Shoemaker, R.H., Hodes, L., Monks, A., Scudiero, D.A., Rubinstein, L., Plowman, J., and Boyd, M.R., J. Natl. Cancer Inst., 1989, vol. 81, p. 1088. https://doi.org/10.1093/jnci/81.14.1088
Monks, A., Scudiero, D., Skehan, P., Shoemaker, R., Paull, K., Vistica, D., Hose, C., Langley, J., Cronise, P., Vaigro-Wolff, A., Gray-Goodrich, M., Campbell, H., Mayo, J., and Boyd, M., J. Natl. Cancer Inst., 1991, vol. 83, p. 757. https://doi.org/10.1093/jnci/83.11.757
ACKNOWLEDGMENTS
The authors thank School of Science, Department of Chemistry, RK University, Rajkot, for providing all the facilities for completion of this work and National Facility for Drug Discovery (NFDD), Rajkot, for providing spectral data and National Institutes of Health (NIH) for evaluation of biological activity.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
The authors declare no conflict of interest.
Supplementary information
Rights and permissions
About this article
Cite this article
Hadiyal, S.D., Lalpara, J.N. & Dhaduk, B.B. Microwave-Assisted In Situ Cyclization of Curcumin Derivatives as Dominant Chemotherapeutic Agents for Leukemia and Colon Cancer. Russ J Org Chem 58, 368–371 (2022). https://doi.org/10.1134/S1070428022030150
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1070428022030150