Abstract
Base-catalyzed three-component condensation of ethyl 4,5-dioxo-4,5-dihydro-1H-pyrrole-3-carboxylates with malononitrile and phthalhydrazide afforded substituted ethyl 3-amino-2-cyano-2′,5,10-trioxo-5′-phenyl-1′,2′,5,10-tetrahydrospiro[pyrazolo[1,2-b]phthalazine-1,3′-pyrrole]-4′-carboxylates which attract interest for medicinal chemistry. The reaction provides a convenient preparative method of synthesis of previously inaccessible spiro[pyrazolo[1,2-b]phthalazine-1,3′-pyrrole] heterocyclic system.
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This study was performed under financial support by the Perm Scientific and Educational Center “Rational Use of Earth’s Interior,” 2021.
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Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 12, pp. 1797–1800 https://doi.org/10.31857/S0514749221120181.
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Dmitriev, M.V., Sabitov, A.A. & Maslivets, A.N. Three-Component Reaction of 1H-Pyrrole-2,3-diones with Malononitrile and Phthalhydrazide. Russ J Org Chem 57, 2077–2079 (2021). https://doi.org/10.1134/S1070428021120289
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DOI: https://doi.org/10.1134/S1070428021120289