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Synthesis of 4-[(3,3-Dimethyl-3,4-dihydroisoquinolin-1-yl)sulfanyl]anilines by the Ritter Reaction

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Abstract

The Ritter cyclocondensation of 2-methyl-3-phenylpropan-2-ol with 4-isocyanatoaniline, 2-methyl-4-thiocyanatoaniline, and ethyl 4-amino-3-thiocyanatobenzoate afforded the corresponding 4-[(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)sulfanyl]anilines. The products can be regarded as substrates for further transforma­tions and potential biologically active compounds.

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Authors and Affiliations

  1. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 614990, Perm, Russia

    A. G. Mikhailovskii & D. A. Peretyagin

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  1. A. G. Mikhailovskii
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  2. D. A. Peretyagin
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Correspondence to A. G. Mikhailovskii.

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Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 12, pp. 1789–1792 https://doi.org/10.31857/S0514749221120168.

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Mikhailovskii, A.G., Peretyagin, D.A. Synthesis of 4-[(3,3-Dimethyl-3,4-dihydroisoquinolin-1-yl)sulfanyl]anilines by the Ritter Reaction. Russ J Org Chem 57, 2071–2073 (2021). https://doi.org/10.1134/S1070428021120265

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