Skip to main content
SpringerLink
Log in

Ultrasound-Mediated Synthesis of Sulfonyl Urea Derivatives and Their In Vitro Antiproliferative Activity

  • Published:
Russian Journal of Organic Chemistry Aims and scope Submit manuscript

Abstract

A series of novel sulfonyl urea derivatives were designed as potential anticancer agents. These compounds were prepared in good yields by the reaction of 1-(3-ethoxy-4-methoxyphenyl)-2-(methanesulfonyl)­ethan-1-amine with various aromatic and aliphatic isocyanates under ultrasonic irradiation. Two of the syn­the­sized sulfonyl urea derivatives showed potent antiproliferative properties comparable to the known anticancer drug doxorubicin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1.
Scheme

Similar content being viewed by others

REFERENCES

  1. Perla, P., Seelam, N., and Bera, R., Russ. J. Org. Chem., 2020, vol. 56, p. 924. https://doi.org/10.1134/S1070428020050280

    Article  CAS  Google Scholar 

  2. Schafer, P.H., Parton, A., Capone, L., Cedzik, D., Brady, H., Evans, J.F., Man, H.W., Muller, G.W., Stirling, D.I., and Chopra, R., Cell. Signalling, 2014, vol. 26, no. 9, p. 2016. https://doi.org/10.1016/j.cellsig.2014.05.014

    Article  CAS  PubMed  Google Scholar 

  3. Hafez, H.N. and El-Gazzar, A.-R.B.A., Curr. Org. Synth., 2020, vol. 17, p. 55. https://doi.org/10.2174/1570179417666191223163225

    Article  CAS  PubMed  Google Scholar 

  4. Zhao, C.R., Wang, R.Q., Li, G., Xue, X.X., Sun, C.J., Qu, X.J., and Li, W.B., Bioorg. Med. Chem. Lett., 2013, vol. 23, p. 1989. https://doi.org/10.1016/j.bmcl.2013.02.034

    Article  CAS  PubMed  Google Scholar 

  5. Štrukil, V., Beilstein J. Org. Chem., 2017, vol. 13, p. 1828. https://doi.org/10.3762/bjoc.13.178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Ashok, D., Ganesh, A., Lakshmi, B.V., and Ravi, S., Russ. J. Gen. Chem., 2015, vol. 85, p. 2141. https://doi.org/10.1134/S1070363215090194

    Article  CAS  Google Scholar 

  7. Ashok, D., Ganesh, A., Vijaya Lakshmi, B., and Ravi, S., Russ. J. Gen. Chem., 2014, vol. 84, p. 1237. https://doi.org/10.1134/S1070363214060309

    Article  CAS  Google Scholar 

  8. Hafez, N.A.A., Hassaneen, H.M.E., Farghaly, T.A., Riyadh, S.M., and Elzahabi, H.S.A., Mini-Rev. Med. Chem., 2018, vol. 18, p. 631. https://doi.org/10.2174/1389557517666170912170027

    Article  CAS  PubMed  Google Scholar 

  9. Prasanna, G.L., Rao, B.V.D., Reddy, A.G., Rao, M.V.B., and Pal, M., Mini-Rev. Med. Chem., 2019, vol. 19, p. 671. https://doi.org/10.2174/1386207322666191024105150

    Article  CAS  PubMed  Google Scholar 

  10. Prasanna, G.L., Abbaraju, V.D.N.K., Bharath, Y., Rao, M.V.B., and Pal, M., Mini-Rev. Med. Chem., 2019, vol. 19, p. 842. https://doi.org/10.2174/1389557519666190130163708

    Article  CAS  PubMed  Google Scholar 

  11. Riggs-Sauthier, J., Duarte, F.J., and Allums-Donald, S., Int. Patent Appl. Pub. no. WO 2012/083153 A1, 2012.

Download references

ACKNOWLEDGMENTS

The authors are thankful to Department of Chemistry, Rayalaseema University, Kurnool, Andhra Pradesh, India, and GVK Biosciences PVT Ltd., Hyderabad, India, for providing laboratory facilities.

Author information

Authors and Affiliations

  1. Department of Chemistry, Rayalaseema University, 518002, Kurnool, Andhra Pradesh, India

    V. Ganapathi, T. R. Prasad, K. R. Valluru, S. Maroju & S. N. R. Mule

  2. GVK Biosciences PVT Ltd., 500076, Hyderabad, Telangana, India

    V. Ganapathi

  3. Department of Chemistry, Osmania University, 500007, Hyderabad, Telangana, India

    V. Guguloth

Authors
  1. V. Ganapathi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. R. Prasad
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. R. Valluru
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Maroju
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. S. N. R. Mule
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. V. Guguloth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. Ganapathi.

Ethics declarations

The authors confirm that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ganapathi, V., Prasad, T.R., Valluru, K.R. et al. Ultrasound-Mediated Synthesis of Sulfonyl Urea Derivatives and Their In Vitro Antiproliferative Activity. Russ J Org Chem 57, 2048–2053 (2021). https://doi.org/10.1134/S1070428021120228

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S1070428021120228

Keywords:

Search

Navigation