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Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic Acids

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Abstract

New substituted 2-[2-(4-nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic acids have been synthe­sized by condensation of 4-nitrobenzohydrazide with 4-aryl-2,4-dioxobutanoic acids, and their intramolecular cyclization in the presence of propionic anhydride afforded the corresponding substituted 3-[2-(4-nitrobenzoyl)­hydrazinylidene]furan-2(3H)-ones. The synthesized compounds were evaluated for their antinociceptive activity.

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Funding

This study was performed under financial support by the “Rational Use of the Earth Interior” Perm Scientific Educa­tional Center, 2021.

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Authors and Affiliations

  1. Perm State National Research University, 614990, Perm, Russia

    E. I. Denisova, D. V. Lipin, K. Yu. Parkhoma, S. V. Chashchina, R. R. Makhmudov & S. A. Shipilovskikh

  2. Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation, 614990, Perm, Russia

    E. I. Denisova, I. O. Devyatkin, S. V. Chashchina & N. M. Igidov

  3. Perm National Research Polytechnic University, 614990, Perm, Russia

    D. A. Shipilovskikh

  4. School of Physics and Engineering, ITMO University, 197101, St. Petersburg, Russia

    S. A. Shipilovskikh

Authors
  1. E. I. Denisova
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  2. D. V. Lipin
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  4. I. O. Devyatkin
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  5. D. A. Shipilovskikh
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  9. S. A. Shipilovskikh
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Correspondence to S. A. Shipilovskikh.

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Additional information

Translated from Zhurnal Organicheskoi Khimii, 2021, Vol. 57, No. 12, pp. 1736–1743 https://doi.org/10.31857/S0514749221120089.

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Denisova, E.I., Lipin, D.V., Parkhoma, K.Y. et al. Synthesis, Intramolecular Cyclization, and Antinociceptive Activity of Substituted 2-[2-(4-Nitrobenzoyl)hydrazinylidene]-4-oxobut-2-enoic Acids. Russ J Org Chem 57, 1955–1960 (2021). https://doi.org/10.1134/S1070428021120083

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