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Synthesis and Docking Study of Novel Pyranocoumarin Derivatives

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Abstract

A new series of fused tricyclic coumarin derivatives were designed, synthesized by a simple and convenient method, starting from 4-hydroxycoumarin and virtually screened by molecular docking on the target protein 3FRZ (PDB ID: 3FRZ), a HCV RNA-dependent RNA polymerase, for potency against hepatitis C virus (HCV). Efficient binding to the target protein was found for most of the synthesized compounds.

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ACKNOWLEDGMENTS

The authors are grateful to Koneru Lakshmaiah Education Foundation, Green Fields, Vaddeswaram, Guntur (Dist.), Andhra Pradesh, India for providing all the required facilities and the financial support.

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Authors and Affiliations

  1. Department of Chemistry, Koneru Lakshmaiah Education Foundation, Green Fields, 522502, Vaddeswaram, India

    S. Durga Karteek

  2. Department of Pharmacy, SANA College of Pharmacy, 508206, Kodad, India

    A. Gopi Reddy

  3. Department of Pharmacy, Sri Ramachandra Medical College and Research Institute, 600116, Chennai, India

    M. Bhuvan Tej

  4. Department of Chemistry, Krishna University, 521001, Machilipatnam, India

    M. V. Basaveswara Rao

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  1. S. Durga Karteek
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Correspondence to M. V. Basaveswara Rao.

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Karteek, S.D., Reddy, A.G., Tej, M.B. et al. Synthesis and Docking Study of Novel Pyranocoumarin Derivatives. Russ J Org Chem 57, 272–282 (2021). https://doi.org/10.1134/S1070428021020196

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