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Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives

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Abstract

A series of N-substituted-6-methyl-4-{4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxyphenyl}-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamides have been synthesized by the condensation of newly synthesized {4-[5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl]methoxy}benzaldehyde with variously substituted acetoacetanilides and urea in the presence of ethanol. The synthesized compounds have been characterized by 1H, 13C NMR, IR spectroscopy, and mass spectrometry. All synthesized compounds were evaluated for in vitro antidiabetic activity using the α-amylase inhibition assay with the 3,5-dinitrosalicylic acid (DNSA) reagent.

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ACKNOWLEDGMENTS

The authors are grateful to the Department of Chemistry, School of Science, RK University (Rajkot) for providing laboratory facilities and National Facility for Drug Discovery (NFDD) for providing spectral data. The authors express their gratitude to the Department of Microbiology, School of Science, RK University, Rajkot for antidiabetic screening.

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Authors and Affiliations

  1. School of Science, Department of Chemistry, RK University, 360020, Rajkot, India

    J. N. Lalpara, M. D. Vachhani, S. D. Hadiyal & G. G. Dubal

  2. School of Science, Department of Microbiology, RK University, 360020, Rajkot, India

    S. Goswami

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  1. J. N. Lalpara
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  2. M. D. Vachhani
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  3. S. D. Hadiyal
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  4. S. Goswami
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  5. G. G. Dubal
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Correspondence to G. G. Dubal.

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Lalpara, J.N., Vachhani, M.D., Hadiyal, S.D. et al. Synthesis and in vitro Antidiabetic Screening of Novel Dihydropyrimidine Derivatives. Russ J Org Chem 57, 241–246 (2021). https://doi.org/10.1134/S1070428021020159

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