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Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines

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Abstract

The reactions of 6-acetyl-3-amino-4-imino-7-methyl-5-phenyl-3,5-dihydro-4H-pyrano[2,3-d]pyrimidine with triethyl phosphite and some electrophilic reagents, namely 1,2-dibromoethane, oxalyl chloride, chloroacetyl chloride, and ethyl chloroacetate, were studied. These one-pot three-component reactions regioselectively afforded four new 11-acetyl-2-ethoxy-10-methyl-12-phenylpyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5λ5]triazaphosphepin-2-ones in 69–73% yields.

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Funding

The authors thank “The Research Center for Advanced Materials Science (RCAMS)” at King Khalid University for funding this work under grant no. RCAMS/KKU/017-20.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, King Khalid University, 61421, Abha, Saudi Arabia

    T. E. Ali, M. A. Assiri & M. H. Meselhy

  2. Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

    T. E. Ali & M. S. A. Hussien

  3. Research Center for Advanced Materials Science, King Khalid University, 61421, Abha, Saudi Arabia

    I. S. Yahia & H. Y. Zahran

  4. Department of Physics, Faculty of Science, King Khalid University, 61421, Abha, Saudi Arabia

    I. S. Yahia & H. Y. Zahran

  5. Department of Physics, Faculty of Education, Ain Shams University, Roxy, 11711, Cairo, Egypt

    I. S. Yahia & H. Y. Zahran

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  1. T. E. Ali
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  2. M. A. Assiri
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  3. I. S. Yahia
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  4. H. Y. Zahran
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  5. M. H. Meselhy
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  6. M. S. A. Hussien
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Correspondence to T. E. Ali.

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Ali, T.E., Assiri, M.A., Yahia, I.S. et al. Regioselective Synthesis of Novel Functionalized Pyrano[2′,3′:4,5]pyrimido[1,6-b][1,2,4,5]triazaphosphepines. Russ J Org Chem 57, 79–84 (2021). https://doi.org/10.1134/S1070428021010115

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  • DOI: https://doi.org/10.1134/S1070428021010115

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