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Synthesis, Characterization, and Comparative Study of Some Heterocyclic Compounds Containing Isoniazid and Nicotinic Acid Hydrazide Moieties

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Abstract

Some new derivatives of six-membered heterocyclic compounds containing isoniazid and nicotinic acid hydrazide fragments have been synthesized according to green procedures with excellent yields. The structures of the synthesized compounds were confirmed by 1H and13C NMR, IR, and mass spectra and elemental analyses. The compounds were screened for their in vitro antibacterial and antifungal activities. The results showed that the isoniazid derivatives are more active than their analogs containng a nicotinic hydrazide moiety.

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ACKNOWLEDGMENTS

The authors are thankful to the Head, Department of Chemistry, M.G. Science Institute, Gujarat University, Ahmedabad, for providing research facilities.

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Authors and Affiliations

  1. Department of Chemistry, M. G. Science Institute, Gujarat University, 380009, Ahmedabad, Gujarat, India

    M. Zala & J. J. Vora

  2. Department of Chemistry, LJ Institute of Applied Sciences, Gujarat University, 380009, Ahmedabad, Gujarat, India

    H. B. Patel

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  1. M. Zala
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  2. J. J. Vora
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  3. H. B. Patel
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Correspondence to M. Zala.

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Zala, M., Vora, J.J. & Patel, H.B. Synthesis, Characterization, and Comparative Study of Some Heterocyclic Compounds Containing Isoniazid and Nicotinic Acid Hydrazide Moieties. Russ J Org Chem 56, 1795–1800 (2020). https://doi.org/10.1134/S1070428020100218

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