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Chemical Transformations of 4-(4-Aminophenyl)-2,6-diphenylpyrimidine

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Abstract

4-(4-Aminophenyl)-2,6-diphenylpyrimidine was synthesized by reaction of (E)-1-(4-aminophenyl)-3-phenylprop-2-en-1-one with benzamidine and was involved in a number of transformations at the amino group, which afforded N-(2,4-dinitrophenyl) and N-acyl derivatives, N-[4-(2,6-diphenylpyrimidin-4-yl)phenyl]-6-methyl-2-(methylsulfanyl)pyrimidin-4-amine, and substituted quinazolines containing a 2,4,6-triphenylpyrimidine fragment on N3. The reaction of 2-methylquinazolines with aromatic aldehydes gave substituted (E)-3-[(4-(2,6-diphenylpyrimidin-4-yl)phenyl]-2-styrylquinazolin-4(3H)-ones.

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Funding

This study was performed at the Russian–Armenian University under financial support by the Ministry of Science and Higher Education of the Russian Federation.

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Authors and Affiliations

  1. Russian–Armenian (Slavonic) University, 0051, Yerevan, Armenia

    A. A. Harutyunyan

  2. Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of Armenia, 0014, Yerevan, Armenia

    A. A. Harutyunyan, S. G. Israyelyan, H. A. Panosyan, M. S. Safaryan & S. V. Dilanyan

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  1. A. A. Harutyunyan
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  2. S. G. Israyelyan
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  3. H. A. Panosyan
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  4. M. S. Safaryan
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  5. S. V. Dilanyan
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Correspondence to A. A. Harutyunyan.

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Harutyunyan, A.A., Israyelyan, S.G., Panosyan, H.A. et al. Chemical Transformations of 4-(4-Aminophenyl)-2,6-diphenylpyrimidine. Russ J Org Chem 56, 1588–1594 (2020). https://doi.org/10.1134/S1070428020090146

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  • DOI: https://doi.org/10.1134/S1070428020090146

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