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Synthesis and Antimicrobial Activity of 2-[5-(R-Benzyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-oxobutanenitrile and [2-(1-Cyano-2-oxopropylidene)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivatives

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Abstract

The reactions of 2-cyano-3-oxobutanethioamide with ethyl 3-aryl-2-bromopropanoates and dialkyl acetylenedicarboxylates afforded a combinatorial library of new 2-[5-(R-benzyl)-4-oxo-1,3-thtiazolidin-2-ylidene]-3-oxobutanenitrile and [2-(1-cyano-2-oxopropylidene)-4-oxo-1,3-thiazolidin-5-ylidene]acetic acid derivatives. The synthesized compounds were evaluated for antimicrobial activity, and the activity of some derivatives against gram-positive Staphylococcus aureus ATCC 43300 exceeded the activity of ceftriaxone taken as a reference drug.

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Horishny, V.Y., Matiichuk, V.S. Synthesis and Antimicrobial Activity of 2-[5-(R-Benzyl)-4-oxo-1,3-thiazolidin-2-ylidene]-3-oxobutanenitrile and [2-(1-Cyano-2-oxopropylidene)-4-oxo-1,3-thiazolidin-5-ylidene]acetic Acid Derivatives. Russ J Org Chem 56, 1557–1561 (2020). https://doi.org/10.1134/S1070428020090092

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