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Heterocyclization of Aromatic Amino Acids: Novel Syntheses and Antibacterial Activity of Fused, Non-fused, and Spiro Polyheterocyclic Derivatives

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Abstract

Commercially available p-aminobenzoic acid was used as a precursor for the synthesis of novel fused, non-fused, and spiro polyheterocyclic derivatives bearing indene, imidazole, pyrazole, and/or triazine nucleus via addition to simple and accessible reagents such as ninhydrin, o-phenylenediamine, and carbon disulfide. The experimental procedures were straightforward and simple, the products were isolated in 15–86% yields, and. their structure was confirmed by spectroscopic data. The synthesized compounds were evaluated for their antibacterial activity against some Gram-positive and Gram-negative bacteria.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Zagazig University, 44519, Zagazig, Egypt

    E. O. Hamed & M. G. Assy

  2. Department of Chemistry, Faculty of Science, Jazan University, 45142, Jazan, Saudi Arabia

    M. M. Galahom

Authors
  1. E. O. Hamed
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  2. M. G. Assy
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  3. M. M. Galahom
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Correspondence to E. O. Hamed.

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Hamed, E.O., Assy, M.G. & Galahom, M.M. Heterocyclization of Aromatic Amino Acids: Novel Syntheses and Antibacterial Activity of Fused, Non-fused, and Spiro Polyheterocyclic Derivatives. Russ J Org Chem 56, 1062–1069 (2020). https://doi.org/10.1134/S1070428020060159

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